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  Indian J Med Microbiol
 

Figure 5: (a) Leukoplakia with hyperplastic epithelium, acanthosis, and hyperkeratinization, suggestive of mild dysplastic features (H and E stain, ×100); (b) p63 stain involves only basal and parabasal cell layer, indicating it to be simple hyperplasia (IHC stain, ×100); (c) photomicrograph showing bulbous rete ridges, altered nuclear cytoplasmic ratio, increased mitoses in the basal layer of cells (Inset: H and E stain, ×400), and hyperparakeratosis, suggestive of moderate dysplasia (H and E stain, ×40). (d) Photomicrograph showing p63 staining mainly basal–parabasal cell layers and few cells in the spinous layer, suggestive of mild dysplasia (IHC stain, ×40)

Figure 5: (a) Leukoplakia with hyperplastic epithelium, acanthosis, and hyperkeratinization, suggestive of mild dysplastic features (H and E stain, ×100); (b) p63 stain involves only basal and parabasal cell layer, indicating it to be simple hyperplasia (IHC stain, ×100); (c) photomicrograph showing bulbous rete ridges, altered nuclear cytoplasmic ratio, increased mitoses in the basal layer of cells (Inset: H and E stain, ×400), and hyperparakeratosis, suggestive of moderate dysplasia (H and E stain, ×40). (d) Photomicrograph showing p63 staining mainly basal–parabasal cell layers and few cells in the spinous layer, suggestive of mild dysplasia (IHC stain, ×40)