ORIGINAL ARTICLE
Year : 2016 | Volume
: 7 | Issue : 2 | Page : 198--202
Evaluation of salivary interleukin-6 in children with early childhood caries after treatment
Medhini Madhavan Menon1, R Varma Balagopal1, Krishnan Sajitha2, Kumaran Parvathy1, G Bhat Sangeetha1, X Mamachan Arun1, Janardhanan Sureshkumar1
1 Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India
2 Department of Biochemistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India
Correspondence Address:
R Varma Balagopal
Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Ponekkara PO, Kochi - 682 041, Kerala
India
Background: The role of cytokines as a marker in the oral inflammatory process in ECC has not been fully explored before and after full mouth rehabilitation. Aims: The aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with ECC and to compare its levels before and after comprehensive full mouth rehabilitation. Methods and Materials: Saliva samples were collected from children with ECC prior to dental treatment and 3-month post treatment. The salivary IL-6 levels were analyzed using the ELISA method. The gingival index was also timely recorded. Oral health awareness sessions were conducted for children and their parents at regular intervals during the 3-month study period. Statistical analysis used: Wilcoxon Signed Rank test compared the levels of salivary IL-6 while, the paired t test compared the values of gingival index before and after treatment. Results: The mean level of salivary IL-6 before and 3 months after treatment had reduced and this reduction was statistically significant (P< 0.000). The gingival index scores had also reduced significantly 3-months post treatment (P< 0.002). Conclusions: Children with ECC when completely rehabilitated and kept under frequent follow up, which includes reinforcement of oral hygiene measures and maintaining a low caries activity state, the level of inflammation (IL-6) can definitely be minimized and thereby improving the quality of life of affected children.
How to cite this article:
Menon MM, Balagopal R V, Sajitha K, Parvathy K, Sangeetha G B, Arun X M, Sureshkumar J. Evaluation of salivary interleukin-6 in children with early childhood caries after treatment.Contemp Clin Dent 2016;7:198-202
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How to cite this URL:
Menon MM, Balagopal R V, Sajitha K, Parvathy K, Sangeetha G B, Arun X M, Sureshkumar J. Evaluation of salivary interleukin-6 in children with early childhood caries after treatment. Contemp Clin Dent [serial online] 2016 [cited 2021 Apr 23 ];7:198-202
Available from: https://www.contempclindent.org/article.asp?issn=0976-237X;year=2016;volume=7;issue=2;spage=198;epage=202;aulast=Menon;type=0 |
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