| REVIEW ARTICLE |
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| Year : 2020 | Volume
: 11
| Issue : 1 | Page : 3-9 |
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Meta-analysis of risk association between interleukin-17a gene polymorphism and chronic periodontitis
PK Sasikumar1, Sheeja S Varghese2, Thanga Kumaran3, Sakthi Saranya Devi4
1 Department of Periodontics, JKKN Dental College, Namakkal, Tamil Nadu, India
2 Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India
3 Department of Periodontics, JKKNDCH, Thiruchengodu, Tamil Nadu, India
4 Department of Oral Medicine Andradiology, KSR Institute of Dental Science and Research, Thiruchengodu, Tamil Nadu, India
Correspondence Address:
Dr. P K Sasikumar
Department of Periodontics, JKKN Dental College and Hospital, Namakkal - 638 183, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ccd.ccd_448_19
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The association of genetic polymorphisms with periodontitis has been studied extensively. The interleukin-7 (IL-17) is a group of cytokines, which comprises six different molecules (IL-17A, B, C, D, E, and F). Among this, IL-17A is the most commonly understood cytokine, and its polymorphism plays a critical role in inflammatory diseases and periodontal inflammation. The present study was aimed at pooling the data available for meta-analysis and to evaluate whether IL-17A (rs2275913) polymorphism is associated with the susceptibility of chronic periodontitis.
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