Contemporary Clinical Dentistry
  Home | About us | Editorial board | Search
Ahead of print | Current Issue | Archives | Advertise
Instructions | Online submission| Contact us | Subscribe |


Login  | Users Online: 353  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 

Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 48-53

Comparative evaluation of locally delivered minocycline and metronidazole in the treatment of periodontitis

1 Department of Periodontology and Implantology, D.A.V. (c) Dental College, Model Town, Yamuna Nagar, Haryana, India
2 Department of Periodontology and Implantology, P.D.M. Dental College, Bahadurgarh, Haryana, India
3 Himachal Institute of Dental Sciences, Ponta Sahib, Himachal Pradesh, India

Correspondence Address:
Ritu Dahiya
Department of Periodontology and Implantology, P.D.M. Dental College, Bahadurgarh, Haryana
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-237X.111615

Rights and Permissions

Objective: The aim of this study was to evaluate and compare the efficacy of subgingivally delivered Minocycline microspheres and 25% Metronidazole gel when used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Materials and Methods: A randomized, controlled, single center study was conducted involving 60 sites in 20 patients suffering from moderate to advanced chronic periodontitis. Each patient contributed three sites which were randomized to three treatment groups: SRP + insertion of Minocycline microspheres at day 1 (Group A), SRP + insertion of Metronidazole gel at day 1 and at day 7 (Group B), and SRP alone (Group C). Gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at day 1, 1 month, and 3 months post therapy. Results: All treatments showed significant reductions in PPD and CAL at 1 and 3 months when compared to baseline values ( P < 0.001). At 3 months, sites treated with minocycline showed an additional reduction in PPD of 0.85 ± 0.03 mm, significantly greater than SRP alone. Differences in mean PPD reduction between Group B and Group C and between Group A and Group B were not significant. At 3 months, difference in CAL gain between Group A and C was 0.50 ± 0.45, which was statistically significant and between Group B and C was 0.35 ± 0.11, which was not found to be statistically significant ( P = 0.20). Differences in relative CAL between Group A and Group B were also not found to be statistically significant ( P = 0.53). Conclusion: The results concluded that treatment with Minocycline microspheres and Metronidazole gel improve PPD and CAL in patients with periodontitis compared to SRP alone.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded390    
    Comments [Add]    
    Cited by others 4    

Recommend this journal