Contemporary Clinical Dentistry

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 4  |  Page : 535--540

Concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies


Raja Sekhar Gali1, Ravindran Chinnaswamy2, Sathya Kumar Devireddy1, Mahaboob Vali Shaik3, Rayadurgam Venkata Kishore Kumar1, Sridhar Reddy Kanubaddy1, Ramesh Babu Vaka1, YS Harish1, Rama Mohan Pathapati3 
1 Department of Oral and Maxillofacial Surgery, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India
2 Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India
3 Department of Pharmacology, Advanced Research Centre, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India

Correspondence Address:
Prof. Raja Sekhar Gali
Department of Oral and Maxillofacial Surgery, Narayana Dental College and Hospital, Nellore - 524 003, Andhra Pradesh
India

Purpose: The aim of this study was to evaluate the bone regeneration potential of concentrated bone marrow aspirate (BMA)-coated hydroxyapatite (HA) for reconstruction of mandibular defects caused by the removal of benign pathologies. Patients and Methods: This prospective clinical study included ten patients with histopathologically proven benign pathologies of the mandible measuring <5 cm anteroposteriorly, who were treated with enucleation or marginal resection, followed by autologous concentrated BMA-coated synthetic biphasic HA (HA and beta-tricalcium phosphate) graft placement. Clinical and radiological evaluations of grafted sites of the mandible were done at 1 week, 1, 3, and 6 months postoperatively using Irwin's radiologic staging and grayscale histogram. Results: All patients (10/10, 100%) had proper incorporation of the graft with the normal adjacent bone. Grayscale histogram revealed the initial stages of graft resorption, followed by formation of new bone-grafted sites. No complications such as infection and total graft loss were encountered except for one patient who had partial wound dehiscence that responded well to local wound care and resuturing. Conclusion: Concentrated BMA-coated synthetic HA effectively promotes bone regeneration in small-to-moderate-sized defects of the mandible.


How to cite this article:
Gali RS, Chinnaswamy R, Devireddy SK, Shaik MV, Kumar RV, Kanubaddy SR, Vaka RB, Harish Y S, Pathapati RM. Concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies.Contemp Clin Dent 2018;9:535-540


How to cite this URL:
Gali RS, Chinnaswamy R, Devireddy SK, Shaik MV, Kumar RV, Kanubaddy SR, Vaka RB, Harish Y S, Pathapati RM. Concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies. Contemp Clin Dent [serial online] 2018 [cited 2019 Nov 16 ];9:535-540
Available from: http://www.contempclindent.org/article.asp?issn=0976-237X;year=2018;volume=9;issue=4;spage=535;epage=540;aulast=Gali;type=0