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REVIEW ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 3-9

Meta-analysis of risk association between interleukin-17a gene polymorphism and chronic periodontitis


1 Department of Periodontics, JKKN Dental College, Namakkal, Tamil Nadu, India
2 Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India
3 Department of Periodontics, JKKNDCH, Thiruchengodu, Tamil Nadu, India
4 Department of Oral Medicine Andradiology, KSR Institute of Dental Science and Research, Thiruchengodu, Tamil Nadu, India

Correspondence Address:
Dr. P K Sasikumar
Department of Periodontics, JKKN Dental College and Hospital, Namakkal - 638 183, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccd.ccd_448_19

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The association of genetic polymorphisms with periodontitis has been studied extensively. The interleukin-7 (IL-17) is a group of cytokines, which comprises six different molecules (IL-17A, B, C, D, E, and F). Among this, IL-17A is the most commonly understood cytokine, and its polymorphism plays a critical role in inflammatory diseases and periodontal inflammation. The present study was aimed at pooling the data available for meta-analysis and to evaluate whether IL-17A (rs2275913) polymorphism is associated with the susceptibility of chronic periodontitis.


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