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Year : 2019  |  Volume : 10  |  Issue : 2  |  Page : 232-238

Correlation of E-cadherin immunohistochemical expression with histopathological grading of oral squamous cell carcinoma

1 Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India
2 Department of Oral Medicine and Radiology, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India
3 Department of Prosthodontics, Crown and Bridge, Triveni Institute of Dental Sciences, Hospital and Research Centre, Bilaspur, Chhattisgarh, India
4 Department of Public Health Dentistry, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India

Correspondence Address:
Dr. Karandeep Singh Arora
House No. 1078, Sector - 19B, UT, Chandigarh - 160 019
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ccd.ccd_624_18

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Objectives: The current research was undertaken with an aim to correlate the expression of E-cadherin with histopathological grading in oral squamous cell carcinoma (OSCC) patients. Further, the objectives of the study were to evaluate the qualitative and quantitative expressions of E-cadherin in OSCC and to correlate the number of tumor cells of OSCC, immunopositive for E-cadherin with histopathological grading of OSCC. Materials and Methods: Immunoexpression of E-cadherin antibody was evaluated in previously diagnosed, paraffin-embedded sections of 20 tissues each of well-differentiated and moderately differentiated OSCC, 17 tissues of poorly differentiated OSCC, and 10 tissues of normal oral mucosa; Chi-square test, analysis of variance, and Tukey's honestly significant difference test were employed for statistical analysis. Results: E-cadherin immunoreactivity was inversely correlated to the loss of cell differentiation. There was a significant decrease in expression of E-cadherin (P < 0.0001) in advanced cases of OSCC. Furthermore, there was a significant reduction in intensity of E-cadherin expression with advancing histological grades of OSCC. Conclusion: From the present study, it is concluded that the reduced expression of E-cadherin may be a reliable indicator of increase in the invasiveness of OSCCs.

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