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Year : 2018  |  Volume : 9  |  Issue : 4  |  Page : 548-553

Distribution of dendritic cells and langerhans cells in peri-implant mucosa

1 Department of Periodontology and Oral Implantology, Kamineni Institute of Dental Sciences, Narketpally, Hyderabad, Telangana, India
2 Consultant Periodontist and Implantologist, Hyderabad, Telangana, India

Correspondence Address:
Dr. Jagadish Reddy Gooty
Room No 211, Kamineni Institute of Dental Sciences, Sreepuram Narketpally, Nalgonda, Hyderabad - 508 254, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ccd.ccd_688_18

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Background: Peri-implant diseases leading to the failure of dental implants is concern in the field of dentistry. Difference in immune response around peri-implant tissues with healthy tissue might be responsible for the hidden cause of peri-implant diseases. Hence, in the current study, the dispersion of the dendritic cell (DC) subpopulations and Langerhans cells (LCs) was evaluated in healthy peri-implant mucosa (HPIM) and healthy mucosa (HM) to know the imbalance in immune homeostasis. Subjects and Methods: A total of 15 nonsmoker participants were selected for the study. First sample of the HM was obtained before the implant placement (Group I) and second sample of peri-implant mucosa was obtained at the time of placement of the gingival former (Group II). Immunochemistry was used to quantify DCs and LCs in the samples. Statistical Analysis Used: To analyze the distribution of cells in the epithelium and lamina propria, Wilcoxon matched pairs test was used. Results: Mean numbers of CD1a (LCs) in the epithelium and lamina propria of Group I and Group II were 25.2 ± 6.41 and 27.47 ± 10.26 and 19.27 ± 7.27 and 12.46 ± 3.04, respectively. Mean numbers of factor XIIIa (DCs) in the epithelium and lamina propria in Group I and Group II were 30.37 ± 5.42 and 86.93 ± 13.99 and 50.47 ± 7.27 and 124.33 ± 10.27, respectively. Statistically significant differences in the number of cells in the epithelium and lamina propria of Group I and Group II were noted (P = 0.001 and P = 0.001). Conclusions: CD1a-positive LCs were more in the epithelium rather than lamina propria in Group II. Higher numbers of factor XIIIa-positive DCs were observed in the lamina propria than epithelium in Group I and II.

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