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Year : 2013  |  Volume : 4  |  Issue : 2  |  Page : 227-230

Paget disease of bone: A classic case report

1 Department of Oral Medicine and Radiology, G. Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, India
2 Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India
3 Department of Oral Medicine and Radiology, PMS College of Dental Sciences and Research, Thiruvananthapuram, Kerala, India
4 Department of Oral Medicine and Radiology, SRM Kattankulanthur Dental College, Kancheepuram, Tamil Nadu, India

Correspondence Address:
Satya Ranjan Misra
Prasanti, Kathogola Road, Mangalabag, Cuttack - 753 001, Odisha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-237X.114858

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Paget disease of bone (PDB) is a chronic progressive disease of the bone of uncertain etiology, characterized initially by an increase in bone resorption, followed by a disorganized and excessive formation of bone, leading to pain, fractures, and deformities. It can manifest as a monostotic or polyostotic disease. The prevalence of PDB is common in the Anglo-Saxon population, but relatively rare in India. The disease is often asymptomatic and commonly seen in an aging population. The diagnosis of the disease is mostly based on radiological examination and on biochemical markers of bone turnover. Markedly elevated serum alkaline phosphatase (SAP) is a constant feature while calcium and phosphate levels are typically within normal limits. It is being successfully treated by biphosphonates, a group of anti-resorptive drugs, thereby decreasing the morbidity and mortality associated with the disease. We report a classic case of PDB with craniofacial involvement resulting in Leontiasis Ossea (lion like face), cotton wool appearance of the skull and elevated SAP.

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