Contemporary Clinical Dentistry
  Home | About us | Editorial board | Search
Ahead of print | Current Issue | Archives | Advertise
Instructions | Online submission| Contact us | Subscribe |


Login  | Users Online: 198  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 

Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 144-149

Evaluation of interleukin -1B (+3954) gene polymorphism in patients with chronic and aggressive periodontitis: A genetic association study

1 Department of Periodontics, I.T.S-CDSR, Murad Nagar, Ghaziabad, Uttar Pradesh, India
2 Institute of Dental Studies and Technologies, Modinagar, Ghaziabad, Uttar Pradesh, India
3 Department Periodontology and Implantology, Bapuji Dental College and Hospital, Davangere, Karnataka, India
4 Department Microbiology, Maratha Mandal Dental College and Research Centre, Belgaum, Karnataka, India

Correspondence Address:
Sujata S Masamatti
24 DDA Flats, Taimoor Enclave, New Friends Colony, New Delhi - 110 065
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-237X.96815

Rights and Permissions

Background: IL-1 cytokines have central roles in the pathogenesis of periodontal disease. Polymorphism in the locus +3954 (C/T) of the human IL-1B gene has been shown to affect the levels of this cytokine. Aim: The aim of the present study was to investigate the association between the IL-1 B (+3954) gene polymorphism and the occurrence of different clinical forms of periodontitis. Materials and Methods : Genomic DNA was obtained from 90 individuals and amplified using the PCR with specific primers flanking the locus +3954 of IL-1B. PCR products were submitted to restriction endonuclease digestion and analyzed by gel electrophoresis, allowing for the determination of the genotypes and detection of the polymorphism. Statistical Analysis: Fisher's exact test was used for comparing the frequency of genotype distributions between groups. Results: The chronic periodontitis group displayed a higher percentage of T alleles (38%) when compared to the aggressive periodontitis group (20%) and to the control group (19%). Conclusion: Our study data states that polymorphism in the locus +3954 of IL-1B gene could be a risk factor for chronic periodontitis in a sample of Indian population of Karnataka state.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded328    
    Comments [Add]    
    Cited by others 11    

Recommend this journal