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ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 144-149

Evaluation of interleukin -1B (+3954) gene polymorphism in patients with chronic and aggressive periodontitis: A genetic association study


1 Department of Periodontics, I.T.S-CDSR, Murad Nagar, Ghaziabad, Uttar Pradesh, India
2 Institute of Dental Studies and Technologies, Modinagar, Ghaziabad, Uttar Pradesh, India
3 Department Periodontology and Implantology, Bapuji Dental College and Hospital, Davangere, Karnataka, India
4 Department Microbiology, Maratha Mandal Dental College and Research Centre, Belgaum, Karnataka, India

Correspondence Address:
Sujata S Masamatti
24 DDA Flats, Taimoor Enclave, New Friends Colony, New Delhi - 110 065
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-237X.96815

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Background: IL-1 cytokines have central roles in the pathogenesis of periodontal disease. Polymorphism in the locus +3954 (C/T) of the human IL-1B gene has been shown to affect the levels of this cytokine. Aim: The aim of the present study was to investigate the association between the IL-1 B (+3954) gene polymorphism and the occurrence of different clinical forms of periodontitis. Materials and Methods : Genomic DNA was obtained from 90 individuals and amplified using the PCR with specific primers flanking the locus +3954 of IL-1B. PCR products were submitted to restriction endonuclease digestion and analyzed by gel electrophoresis, allowing for the determination of the genotypes and detection of the polymorphism. Statistical Analysis: Fisher's exact test was used for comparing the frequency of genotype distributions between groups. Results: The chronic periodontitis group displayed a higher percentage of T alleles (38%) when compared to the aggressive periodontitis group (20%) and to the control group (19%). Conclusion: Our study data states that polymorphism in the locus +3954 of IL-1B gene could be a risk factor for chronic periodontitis in a sample of Indian population of Karnataka state.


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