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 Table of Contents  
Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 249-252  

Central giant cell granuloma mimicking an adenomatoid odontogenic tumor

1 Department of Oral Medicine and Radiology, Syamala Reddy Dental College and Research Centre, Bangalore, India
2 Department of Oral Medicine and Radiology, Mahatma Gandhi Dental College and Hospital, Jaipur, India

Date of Web Publication21-Oct-2011

Correspondence Address:
Deepak Daryani
Department of Oral Medicine and Radiology, No. 2, Defence Colony, 1st Main, Indira Nagar, Bangalore - 560 038
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-237X.86483

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Central giant cell granulomas are non-neoplastic lesions of unknown etiology. They affect females more than males with the mandibular anterior region being the most common site of occurrence. Clinically central giant cell granulomas present as asymptomatic, expansile swellings causing deviation of associated teeth. Radiologically they usually presents as multilocular lesions causing expansion or perforation of cortical bone. Central giant cell granulomas are usually confused as other lesions both clinically and radiologically, and a definitive diagnosis can be made only histologically. We report here a rare case of central giant cell granuloma in association with congenitally missing tooth which was misdiagnosed to be an adenomatoid odontogenic tumor both clinically and radiologically. This case report also highlights yet another unique presentation of central giant cell granulomas that is in association with a congenitally missing maxillary lateral incisor.

Keywords: Adenomatoid odontogenic tumor, central giant cell granuloma

How to cite this article:
Daryani D, Gopakumar R. Central giant cell granuloma mimicking an adenomatoid odontogenic tumor. Contemp Clin Dent 2011;2:249-52

How to cite this URL:
Daryani D, Gopakumar R. Central giant cell granuloma mimicking an adenomatoid odontogenic tumor. Contemp Clin Dent [serial online] 2011 [cited 2018 May 24];2:249-52. Available from:

   Introduction Top

Giant cell granuloma is described as a benign lesion affecting the mandible and maxilla that consists of a massive fibrohistiocytic proliferation with numerous heavily hemosidrin laden multinucleated giant cells. [1] Jaffe in 1953 described central giant cell granulomas (CGCG) as an idiopathic non-neoplastic proliferative lesion. CGCG is known to occur in individuals less then 30 years of age with definite female predeliction (2:1). It accounts for approximately 7% of all benign tumors of the jaws. [2] Many times it may be totally asymptomatic and a coincidental finding during a routine radiographic examination. [3] They are more prevalent in the mandible, particularly the anterior region than the maxilla. [4] Apart from jaw bones, CGCG has also been reported to occur in small bones of hands and feet. [5] Radiographically it presents usually as multilocular, expansile radiolucency displacing the teeth, sometimes causing root resorption and cortical perforation. [6]

The treatment of choice for CGCG is excision and currattage followed by bone grafting. [7] The conservative treatment approach includes intralesional calcitonin, intralesional steroids, antiangiogenic therapy, and radiotherapy. [8]

We report an unusual case of CGCG in the maxillary anterior region associated with a congenitally missing tooth mimicking an adenomatoid odontogenic tumor.

   Case Report Top

A 15-year-old girl came to the department of Oral Medicine and Radiology with the chief complaint of a swelling on the left upper anterior teeth region. She gave a history of noticing a peanut sized, assymptomatic swelling 2 months back which was gradually growing. She also gave history of noticing mobility and dull pain in the teeth associated with the swelling. The patient consulted a dentist with the above complaint following which root canal treatment was done in two teeth related to the swelling. But when patient noticed further growth of swelling she reported to our department. There was no history of trauma or discharge from the swelling. Patient gave history of congenitally missing lateral incisors.

There was no significant past medical history, family history, or personal history. On general examination she was moderately built and nourished, alert, responsive, and cooperative. Vital signs were all within the normal range with no signs of pallor, cyanosis, icterus, clubbing, and edema.

Extraorally, a solitary ill-defined swelling was noticed unilaterally on the left side of the face in the region of ala of the nose. Swelling was roughly oval in shape, measuring approximately 2.5 cm in diameter, extending superoinferiorly from 0.5 cm above the ala of nose to the vermillion border of upper lip, mediolaterally 0.5 cm lateral to corner of mouth to the nasolabial fold, causing mild asymmetry of face. The skin over the swelling appeared normal. Swelling had caused the mild uplifting of the left ala of nose.

On palpation the swelling was bony hard, nontender, not compressible, and not reducible. Skin over swelling was pinchable and normal.

Intraorally, a well-defined solitary swelling was noticed in the left anterior maxilla, measuring 3 cm in its greatest dimensions, involving both the labial and palatal aspect. Swelling was completely obliterating the labial vestibule [Figure 1] with respect to 21, 22, 23, 24, extending palatally to involve the midpalatine raphe [Figure 2]. The mucosa over the swelling appeared normal.
Figure 1: Swelling obliterating the labial vestibule

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Figure 2: Swelling extends palatally till the midline

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On palpation the swelling over the labial vestibule was bony hard and not mobile. No egg shell crackling was noticed and there were no areas of fluctuance. Palatally, the swelling was soft in consistency, nontender, nonmobile, noncompressible, nonreducible with no areas of eggshell crackling, or fluctuance.

Examination of teeth revealed missing maxillary lateral incisors bilaterally. A total of 21 and 23 were mobile, mildly tender, and endodontically treated.

On summarizing the clinical findings, a young patient with the swelling in the maxillary anterior region associated with congenitally missing lateral incisors causing the bicortical expansion, mobility of associated teeth, lead us to give a provisional diagnosis of dentigerous cyst. Differential diagnosis considered were radicular cyst, calcifying epithelial odontogenic cyst, adenomatoid odontogenic tumor, fibrous dysplasia, desmoplastic ameloblastoma, and central giant cell granuloma.

Radicular cyst was considered as the associated teeth were endodontically treated. Considering the occurrence of this swelling associated with a missing tooth in a young female patient, the adenomatoid odontogenic tumor was included in the differential diagnosis.

Monostotic fibrious dysplasia was considered as it is known to have a definite female predeliction and presents as an asymptomatic bony swelling commonly affecting maxilla, causing expansion, and deviation of associated teeth.

Calcifying the epithelial odontogenic tumor was also considered in the differential diagnosis as it has wide age distribution and occurs equally in both the jaws usually anterior to 1 st molar. It usually causes expansion, cortical plate perforation, and displacement of associated teeth.

Vitality test revealed that all the teeth were vital except 21 and 23. Fine needle aspiration was done by using 20-gauge needle which gave negative aspiration indicating the absence of fluid within the swelling. Negative aspiration ruled out all the cystic lesions.

Radiographic investigations included panoramic radiograph, occlusal radiograph, and intraoral periapical radiograph which revealed an inverted pear shaped radiolucency with ill-defined and irregular borders in the maxillary anterior region on the left side measuring approximately 3cm×2 cm. It involved the entire alveolar bone in between 21 and 23 (22 was missing), extending from the medial aspect of 23 to the mid-palatine suture [Figure 3]. Internal appearance of the lesion was hazy with no evidence of calcification [Figure 4]. The associated teeth, i.e., 21 and 23, were endodontically treated, tilted toward each other occlusanally with no evidence of external root resorption. Maxillary sinus was intact. These radiological features ruled out the possibility of fibrous dysplasia, calcifying epithelial odontogenic tumor, and desmoplastic ameloblastoma.
Figure 3: Panoramic radiograph showing the extensions of the lesion

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Figure 4: Intraoral periapical radiograph revealing inverted pear-shaped radiolucency

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Further investigations planned for the case were a complete hemogram, serum calcium, phosphate, and alkaline phosphatase which were found to be within normal limits.

Based on history, clinical features, radiological features, and other investigations we considered a diagnosis of the adenomatoid odontogenic tumor.

An excisional biopsy was done along with the extraction of 21 and 23 under local anesthesia. The lesion was surgically excised [Figure 5]. An irregular firm mass of tissue was obtained which was reddish brown in color. Cystic fluid was not encountered during surgery. The patient was prescribed antibiotics and analgesics and recalled after 7 days for suture removal.
Figure 5: Excisional biopsy of the lesion

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Histopathological examination of the specimen revealed the presence of numerous multinucleated giant cells. Giant cells were irregular in shape, contained 4-20 nuclei approximately, and were dispersed throughout the lesional tissue. Some of these nuclei were compact whereas others were vesicular. Spindle-shaped cells and cells with vesicular nucleus were also seen surrounding the giant cells [Figure 6]. The microscopic picture was suggestive of central giant cell granuloma. Histopathologically it is difficult to distinguish between CGCG and brown tumor of hyperparathyroidism. Normal levels of serum calcium, phosphorous, and alkaline phosphatase in this case ruled out hyperparathyroidism. Hence we gave the final diagnosis of central giant cell granuloma.
Figure 6: Histology of the specimen revealing numerous irregular giant cells dispersed throughout the lesional tissue

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Sutures were removed after 7 days. There were no signs of infection and surgical site were healing appropriately. Antibiotics and analgesics were discontinued. A follow-up of the case was done every 2 months for 1 year. No signs of recurrence of the lesion were noticed clinically or radiologically even after 1 year [Figure 7]. A removable partial denture was given after 2 months of surgery. After 1 year of follow-up a fixed partial denture was fabricated with 11 and 24 as abutment teeth.
Figure 7: Postoperative follow-up panoramic radiograph after 10 months

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   Discussion Top

Giant cell granulomas are mysterious lesions of unknown etiology. CGCG is diagnosis of exclusion and can be confirmed only histologically as we saw in this case. What made our case very peculiar was occurrence of CGCG in maxillary anterior region which is the less common site in association with a missing tooth. The association of two endodontically treated teeth with the lesion made it all the more interesting.

A thorough literature review does not provide any information regarding the relationship between CGCG and congenitally missing tooth. Farrier et al. conducted a 10-year review of occurance and treatment of CGCG and reported various presentations of the lesion such as pain, swelling, paresthesia, asymmetry, as periapical pathology, malocclusion, mobility of teeth, and as assymptomatic lesion but did not mention about concurrent occurrence of CGCG with congenitally missing tooth. [8] Site predilection for CGCG in the mandibular anterior lesion mostly occurring on the right side whereas in our case it occurred on the left maxillary anterior region. Trauma is considered an important etiological factor whereas in our case there was no such history.

The unusual case of CGCG in the anterior maxilla associated with the congenitally missing tooth shows us yet another unique way in which these lesions may present in oral cavity. Therefore, it also suggests that CGCG should be considered in the differential diagnosis of swellings of jaws. Further a possible etiology of CGCG as odontogenic in origin can also be suggested and further research can be planned in this direction.

   References Top

1.Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumours. 2 nd ed. Berlin, Germany: Springer- Verlag; 1991. p. 31.  Back to cited text no. 1
2.Austin LT, Dahlin DC, Royer RQ. Giant cell reparative granuloma and related conditions affecting the jaw bones. Oral Surg Oral Med Oral Pathol 1959;12:1285-95.  Back to cited text no. 2
3.Chuong R, Kaban LB, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: A clinicopathologic study. J Oral Maxillofac Surg 1986;44:708-13.  Back to cited text no. 3
4.Sidhu MS, Parkash H, Sidhu SS. Central giant cell granulomas of jaws: Review of 19 cases. Br J Oral Maxillofac Surg 1995;33:43-6.  Back to cited text no. 4
5.Yamaguchi T, Dorfman HD. Giant cell reparative granuloma: A comparative clinopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol 2001;9:189-200.  Back to cited text no. 5
6.Kaffe I, Ardekian L, Taicher S, Littner MM, Buchner A. Radiological features of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;81:720-6.  Back to cited text no. 6
7.Ficarra G, Kaban LB, Hansen LS. Central giant cell lesions of the mandible and maxilla: A clinicopathologic and cytometric study. Oral Surg Oral Med Oral Pathol 1987;64:44-9.  Back to cited text no. 7
8.Farrier SL, Farrier JN, Smart MK, Nash ES. A 10-year review of the occurrence and treatment of central giant cell granulomas, in a District General Hospital. J Oral Pathol Med 2006;35:332-7.  Back to cited text no. 8


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]

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